Clinical Human Trial of Goyamin Shows Reduced LDL Cholesterol Levels

In a randomized, double-blind, placebo-controlled clinical trial, participants who received the recommended daily dose of Goyamin experienced a drop in LDL cholesterol by an average of 4%, with some levels dropping by as much as 37%.

Abstract

Dyslipidemia is exemplified by high levels of low-density lipoprotein cholesterol (LDL-C) and represents a risk factor for cardiovascular diseases and requires therapeutic intervention. Several experimental studies suggest that bitter melon (Momordica charantia) improves lipid metabolism in animal models of dyslipidemia and diabetes. This study evaluated the effects of bitter melon extracts on lipid metabolism following a 30-day treatment period in Japanese adults. This randomized, double-blind, placebo-controlled trial included 43 adult volunteers who received either 100 mg of hot-water extracts of bitter melon (n = 23) or a placebo (n = 20) three times daily for 30 days. The body weight, blood pressure, and levels of LDL-C and other blood parameters of each subject were measured before and after the study period. The results showed that the intervention group exhibited significantly lower LDL-C levels (P = 0.02) as compared with the control group, and there were no significant changes in either group in terms of body weight, body mass index, systolic pressure, diastolic pressure, total cholesterol, high-density lipoprotein cholesterol, triglycerides, or blood glucose. These results suggested that bitter melon extracts might effectively lower LDL-C levels in humans and exhibit potential therapeutic value for the management of dyslipidemic conditions.

Results

Among the 47 recruited subjects, two were excluded because they were receiving continuous drug therapy (pranlukast hydrate and metformin), and two other were excluded after failing to attend the second visit. There was no significant difference in the male: female ratios of the control (n = 20) and intervention (n = 23) groups (Table 1). Table 2 shows the changes in metabolic parameters of the subjects from baseline to post intervention. No significant differences were observed between the control and intervention groups at baseline. The intervention group showed significantly decreased LDL-C levels at the second visit (-5.7 ± 18.5 mg/dL) as compared with the control group (+12 ± 27.3, P = 0.02). There was no significant difference in changes in body weight, BMI, blood pressure, total cholesterol, HDL-C, TGs, glucose, and glycated hemoglobin between the control and intervention groups. Multiple regression analysis revealed that the intervention group had a significantly increased likelihood of lower LDL-C levels after adjusting for sex, age, and baseline body mass index (Table 3). Baseline LDL-C ≥140 mg/dL was observed for 6 subjects in the control group and 9 subjects in the intervention group compared with 7 subjects in each group at the second visit. Furthermore, baseline LDL-C ≥120 mg/dL was observed for 10 subjects in the control group and 14 subjects in the intervention group compared with 11 subjects in each group at the second visit. Among the subjects with baseline LDL-C equal to or exceeding 120 mg/dL, the mean changes were +12.6 ± 25.8 mg/dL in the control group and -9.3 ± 17.9 mg/dL in the intervention group (P = 0.02). Figure 1 shows the changes in LDL-C levels in all subjects in the control and intervention groups and those with baseline LDL-C ≥120 mg/dL.

​Original Scientific Paper

Hiroki Kinoshita and Yasuyuki Ogata,
“Effect of Bitter Melon Extracts on Lipid Levels in Japanese Subjects: A Randomized Controlled Study,”

Evidence-Based Complementary and Alternative Medicine, vol. 2018, Article ID 4915784, 6 pages, 2018.

https://doi.org/10.1155/2018/4915784.

Goyamin Okinawan bitter melon
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